Tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50 = 1.2 nM).1 It is selective for PDE5 over PDE1-4 and 7-10 (IC50s = 9.2-280 μM), however, it does also inhibit PDE11 (IC50 = 11 nM). In vivo, tadalafil (10 mg/kg) decreases production of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 and improves renal function in a rat model of ischemia/reperfusion injury.2 It also reduces development of tobacco smoke-induced emphysema and pulmonary hypertension in mice.3 Formulations containing tadalafil have been used to treat erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.
Formal Name
(6R)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12aR-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
CAS Number
171596-29-5
Molecular Formula
C22H19N3O4
Formula Weight
389.4
| Product More Specifications | |
| Specification | Purity ≥98% Formulation A crystalline solid Solubility(Learn about Variance in Solubility)
max 221, 284, 292 nm SMILES O=C1N(C)CC(N2[C@H](C3=CC=C(OCO4)C4=C3)C5=C(C6=CC=CC=C6N5)C[C@@]21[H])=O InChi Code InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1 InChi Key WOXKDUGGOYFFRN-IIBYNOLFSA-N Storage -20°C |
| Made In | USA |
- Stock: Pre Order
- Model: Cayman
- SKU: 14024
