Product Overview
Baicalin is a flavonoid that has been found in S. baicalensis and has diverse biological activities. It reduces myocardial apoptosis and increases cardiac microvessel levels of endothelial nitric oxide synthase (eNOS) in a rat model of ischemia-reperfusion injury when administered at doses of 30 and 100 mg/kg. Baicalin (50 and 80 mg/kg) increases the number of intratumor CD8+ T cells and reduces tumor volume in an H22 murine hepatocellular carcinoma model. It reduces LPS-induced cortical production of reactive oxygen species (ROS) and levels of IL-1β and TNF-α in a mouse model of neuroinflammation. Baicalin decreases body weight, increases the number of rats with regular estrous cycles, and ameliorates follicular development in a mouse model of dehydroepiandrosterone-induced polycystic ovary syndrome (PCOS).4 It also decreases immobility time in the forced swim test in a mouse model of depression induced by chronic mild stress.
Formal Name
5,6-dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl-β-D-glucopyranosiduronic acid
CAS Number
21967-41-9
Synonyms
- Baicalein 7-glucuronide
Molecular Formula
C21H18O11
Formula Weight
446.4
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/mL
- DMSO: 5 mg/mL
- PBS (pH 7.2): 1 mg/mL
λmax
215, 246, 277, 313 nm
SMILES
OC1=C(O)C(C(C=C(C2=CC=CC=C2)O3)=O)=C3C=C1O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O4
InChi Code
InChI=1S/C21H18O11/c22-9-6-10(8-4-2-1-3-5-8)30-11-7-12(14(23)15(24)13(9)11)31-21-18(27)16(25)17(26)19(32-21)20(28)29/h1-7,16-19,21,23-27H,(H,28,29)/t16-,17-,18+,19-,21+/m0/s1
InChi Key
IKIIZLYTISPENI-ZFORQUDYSA-N
Origin
Plant/Radix scutellariae
- Stock: Pre Order
- Model: Cayman
- SKU: 19843
