Berberine (chloride) 1 G

Product Overview

Berberine is an isoquinoline alkaloid that has been found in C. fenestratum and has diverse biological activities.It induces frameshift mutations and gene crossovers in haploid and diploid strains of S. cerevisiae in the exponential growth phase, respectively, when used at a concentration of 50 µg/ml. Berberine is active against the S. aureus strains ATCC 25922 and NCTC 8530 (MIC = 250 µg/ml for both) It decreases contusion volume, ventricle enlargement, and neurological deficits in a mouse model of controlled cortical impact-induced traumatic brain injury (TBI) when administered at a dose of 10 mg/kg.Berberine (50 mg/kg) reduces serum LDL cholesterol levels in hamsters fed a high-fat high-cholesterol diet.⁵

WARNING This product is not for human or veterinary use.

Formal Name

5,6-dihydro-9,10-dimethoxy-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, monochloride

CAS Number

633-65-8

Synonyms

• BBR
• Umbellatine
• NSC 163088
• NSC 646666

Molecular Formula

C₂₀H₁₈ClNO₄

Formula Weight

371.8

Formulation

A crystalline solid

Solubility

• DMF: 500µg/ml
• DMSO: 25 mg/ml
• DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml
• Ethanol: 500µg/ml

λ_max

230, 266, 348, 431 nm

SMILES

COC1=C2C(C=C3[N+](CCC4=C3C=C5C(OCO5)=C4)=C2)=CC=C1OC.[Cl-]

InChi Code

InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1

InChi Key

VKJGBAJNNALVAV-UHFFFAOYSA-M

Origin

Synthetic