Carboxypeptidase B from porcine pancreas 170 units/MG, 5 g

Product Details  Carboxypeptidase B from porcine pancreas 170 units/MG CAS No    [9025-24-5] Product Code    FC45842 MDL No    MFCD00081476 Smiles    CC(C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)SCC3=CC=CC=C3)NC(=O)CCC(=O)OCarboxypeptidase B is a proteolytic enzyme, which cleaves peptide bonds at the carboxyl side of basic amino acids. It is used as an inhibitor of epidermal growth factor (EGF) in cell culture. Carboxypeptidase B has been shown to be active against human serum and other proteolytic enzymes, such as papain and pepsin. Carboxypeptidase B hydrolyzes proteins by removing terminal lysine residues and esterifies hydroxyl groups on the amino acid side chain to form a stable acyl-enzyme intermediate. This enzyme is used as a prodrug for oral administration of carboxypeptidase A in pancreatic cancer treatment. The inhibition of EGF by carboxypeptidase B has been shown to inhibit tumor growth in vivo by inducing apoptosis through the activation of caspases.